Cats and dogs may help spread life-threatening superbugs to their owners, scientists have warned.

They harbour a protein that makes bacteria resistant to antibiotics and could pass it on to people, according to new research.

It’s been found in our favourite pets, including ‘man’s best friend’, at a small animal hospital in Britain.

The gene, known as optrA, enables blood poisoning bacteria called enterococci to become immune to linezolid.

The medication is used as a last resort for treating potentially deadly infections in humans.

These include MRSA (methicillin-resistant Staphylococcus aureus) and streptococci, two of the leading causes of sepsis.

Study leader Dr Katie Hopkins, from Public Health England (PHE), said: “We believe this is the first report of optrA-positive enterococci isolated from companion animals in the UK.

“This is concerning as transmission of this organism to owners carries the potential for spread to other bacteria, including Staphylococcus aureus. This may lead to difficult-to-treat infections.

“In order to minimise transmission of resistant bacteria between companion animals and people veterinary surgeries need to ensure adequate cleaning takes place and pet owners should wash their hands after handling pets.”

Linezolid is not given to animals in the UK. But blood samples from the cats and dogs suggested they carry bacteria resistant to it.

Dr Hopkins said optrA is key to this process and could be spread between different populations of bugs among cats, dogs – and humans.

She told the European Congress of Clinical Microbiology & Infectious Diseases in Amsterdam: “Linezolid is not licensed for veterinary use in the UK.

“But optrA is also involved in resistance to florfenicol which is used in animals. This is an antibiotic used to treat infections in cattle and poultry.”

Dr Hopkins said: “However, standard protocols for the management of colonised or infected animals should prevent transmission to veterinary staff, and therapeutic options for example, ampicillin or glycopeptides, are available should an infection occur.”

Linezolid resistance is rare in enterococci but has been detected in lab samples from both humans and animals.

It’s usually found inside the genes of chromosomes, making the resistance mechanism stable and incapable of spreading to other bacteria.

But in recent years genes causing resistance to linezolid, such as optrA, have been identified on mobile bits of DNA called plasmids that can spread to other bacteria.

The alarm was raised during routine testing of a sample of Enterococcus faecalis from a cat wound swab at PHE’s veterinary antimicrobial resistance lab.

The bug inhabits the gastrointestinal tracts of humans and other mammals. It can cause a variety of hospital-acquired diseases, in particular urinary tract infections.

Subsequently, three further isolates of the same bacteria from two other cats and one dog from the same hospital but different households, were analysed.

The four wound swabs were confirmed to be resistant to linezolid and another antibiotic called gentamicin.

Worryingly all were positive for optrA and there was evidence of transmission between animals.

Dr Hopkins said: “Our findings further the ‘One-Health’ view antibiotic-resistant bacteria can be shared by animals and humans, although the direction of transfer is often difficult to prove.

“We currently do not know the prevalence of linezolid-resistant enterococci …read more

Source:: Daily times

      

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Cats and dogs may spread life-threatening superbugs to their owners

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