Manchester United return to Premier League action on Monday night to take on Everton under the lights at Old Trafford.
Ruben Amorim’s side are unbeaten in their last five, needing a late equaliser from Matthijs de Ligt to rescue a point against Tottenham before the international break.
Sesko was forced off late on in that game with a knee problem, prompting fears over the international break having also not joined up with the Slovenia squad.
The 22-year-old has avoided any serious damage but is still facing a number of weeks on the sidelines, immediately ruling him out of the visit of the Toffees.
Speaking on Friday, Ruben Amorim was unable to put a specific timeline in place for Sesko’s return – but does hope to have him available again by the time Amad Diallo and Bryan Mbeumo head off on international duty for the Africa Cup of Nations.
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As it stands, the game against Bournemouth on 15 December could be their last game before jetting off to join up with the Ivory Coast and Cameroon squads respectively.
Until then, Matheus Cunha may be asked to operate through the middle as he has already done this season. Joshua Zirkzee is still to start a Premier League game this season but is also an option to lead the line or occupy one of the no10 roles.
Teenage striker Chido Obi may also be hopeful of earning more minutes with the first-team having made eight appearances under Amorim last season.
Harry Maguire has been ruled out of Monday’s game with an injury with Kobbie Mainoo also missing from training on Friday.
The midfielder still has a chance of recovering in time however with Amorim hopeful he will be back in training on Saturday.
Lisandro Martinez is desperate to return to action having not featured since suffering his anterior cruciate ligament injury in February.
Amorim says the Argentina international is ‘close’ but provided no further details on when he plans to bring him back into the side.
Man Utd XI to face Everton – Metro prediction
Zirkzee scored two goals in this fixture last season but Cunha could be given the nod ahead of him with Mason Mount coming back into the side.
Cunha, who has just one goal for his new club, started at centre forward ahead of Sesko in the first three games of the season, returning to the role in away games against Liverpool and Tottenham last time out.
Man Utd vs Everton TV channel and kick-off time
Manchester United vs Everton kicks off at 8pm on Monday 24 November.
You can watch the match live on Sky Sports Premier League and Sky Sports Main Event with streaming also available through the Sky Go app and NOW TV for subscribers.