Beloved Star Has Overcome 30 Hospitalizations Amid Health Battle

Christina Applegate has been a Hollywood staple for decades, effortlessly blending comedy and heart in every role she takes on. But behind the scenes, she’s been facing a crazy uphill battle. Since being diagnosed with multiple sclerosis (MS) in 2021, Applegate has “been in the hospital upwards of 30 times” due to complications from the disease, she revealed in an interview with InStyle. Despite the physical and emotional toll, she continues to show up; not just for herself but for the millions of people living with the condition.

Christina Applegate’s Renowned Roles

Let’s be real: Applegate has been stealing scenes since the ‘80s. Most of us were introduced to her as Kelly Bundy in “Married… with Children,” where she perfected the art of delivering hilariously clueless one-liners. But she didn’t stop there. She dominated rom-coms (“The Sweetest Thing”), crushed it in cult-favorite comedies (“Anchorman”), and gave us one of TV’s best dark dramedy performances in “Dead to Me.” Her work has earned her critical acclaim, awards, and a fanbase that adores her.

Even after her MS diagnosis, she powered through filming the final season of “Dead to Me,” despite the immense physical challenges. She’s since stepped back from on-screen roles, but she’s not disappearing. She’s found new ways to connect with fans, like her podcast MeSsy, where she talks candidly about life with MS; because if there’s one thing Applegate does best, it’s keeping it real.

How MS Has Changed Her Life

MS is relentless. It attacks the central nervous system, causing everything from fatigue and chronic pain to mobility issues (per Johns Hopkins Medicine). For Applegate, that has meant re-learning how to navigate daily life while managing symptoms that often land her in the hospital. Thirty hospitalizations in just a few years? That’s no small thing.

Still, she’s not letting it silence her. She’s been brutally honest about the reality of MS, balancing vulnerability with the sharp wit we’ve always loved. Finding some humor in a tough situation, Applegate explained that her body is “the fight club” and “everyone’s fighting with each other,” (per InStyle) And yet, through it all, she’s raising awareness, advocating for others, and proving that even on the hardest days, she’s still Christina Applegate!

MS may have changed her life, but it hasn’t changed who she really is. She’s still a powerhouse, still an icon, and still one of the most authentic voices in Hollywood.

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