Spurs hosted the Magpies in the evening kick-off, with Omar Marmoush starting up front just days after completing his loan transfer from Manchester City.
He is the second forward to arrive from the Etihad in the last week, after the north Londoners signed Savio in a deal worth up to a staggering £85million.
Many have questioned the signing given the winger did not have a great impact at City under Pep Guardiola, but he enjoyed a perfect debut in the Carabao Cup win over Charlton Athletic on Tuesday night.
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The Brazilian came off the bench to score and assist in a 5-1 win and was fully expected to be involved in some capacity on Saturday.
But when the line-ups were announced, Savio’s name was nowhere to be seen, with De Zerbi revealing he has sustained an injury set-back.
‘There was bad news yesterday, before training in the afternoon,’ the Italian head coach told Sky Sports shortly before kick-off.
Omar Marmoush made his Tottenham debut against Newcastle (Photo: Getty)
‘He [Savio] suffered muscle fatigue and the medical staff obviously didn’t want to take a risk. I agree with them.
‘It’s not the right moment [to play], especially because he didn’t work in the last 10 days. 20 minutes against Charlton, was tough to rest for the days after.
‘But for the next game, I think there will be no problem.’
Spurs’ treatment room is filling up already, with James Maddison and Pape Matar Sarr sidelined, while Xavi Simons, Wilson Odobert and Dejan Kulusevski remain long-term absentees.
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